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Understanding the role of resveratrol in major neurological and lifestyle diseases: an insight into molecular mechanisms and druggability

Amarendranath Choudhury, Rudrarup Bhattacharjee, Dattatreya Adapa, Indrajeet Chakraborty, Tuhin Subhra Banerjee, Dhilleshwara Rao Vana

Progressive research of last five decades has gathered encourageable data on many edible plant products which showed protective and ameliorative efficacy against various disease profiles. Several medicinal formulations also have targeted such plant products as an alternative drug-source for the treatment of cardiovascular complications, ageing, cancer, arthritis, type 2 diabetes, and neurodegenerative disorders. Among several phytocomponents, Resveratrol (RES) is notable for robust functional contributions and ameliorative properties. RES is considered as one of the most potent naturally occurring polyphenol to fight against oxidative stress, inflammation, and apoptosis. RES is abundantly found in grapes, red wine, peanuts, and some berries. Preclinical experimental studies carried out in this regard, have shown that RES possess numerous biological activities, with possible therapeutic effects in the prevention and treatment of many commonly occurring diseases. In oral administration spectrum, RES was found to be rapidly absorbed by human body; but, owing to high rate of metabolism, exhibiting relatively low bioavailability. In short-term supplementation, it significantly improves the metabolic disorders in patients with type 2 diabetes and other glucose and lipid-induced complications. Experimental studies suggested that, RES exerts beneficial contribution in the prevention of neurodegenerative disorders and cancer; however, the exact mechanisms of action are yet to demonstrate. Moreover, clinical trials are currently very limited and therefore, more research is the need of time. In the present review we have accumulated most of the beneficial contributions of RES and highlighted the possible therapeutic interventions against major disease profiles.