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The use of TyG and AIP: Evolution of indexes in atherosclerosis management

Anastasia V. Poznyak, Vasily N. Sukhorukov, Mikhail A. Popov, Shuzhen Guo, Andrey V Grechko, Alexander N. Orekhov

The pathogenesis of atherosclerosis is complex and multifaceted. This directly affects our understanding of this pathology, its definition and treatment. One of the important indicators that help in determining the disease or predisposition to it are various indices. Among these indices, triglyceride-glucose index and plasma atherogenicity index stand out. The triglyceride-glucose index (TyG) is a reliable alternative marker for determining insulin resistance. To date, quite a lot of research has been conducted aimed at studying TyG. According to the results of these studies, it was found that the TyG index is directly related to the development of CVD. Also, other studies provide convincing evidence that in various clinical scenarios, the risk of CAD is associated with the plasma Atherogenicity Index (AIP). In this review, we have considered these two indices and tried to draw conclusions about their applicability.