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Recent advances in biocatalyst development in the pharmaceutical industry

Mingzi M Zhang, Xiaoyun Su, Ee Lui Ang & Huimin Zhao

Biocatalysts are increasingly employed as more efficient and environmentally safer alternatives to traditional chemical catalysts in the manufacturing of fine chemicals. This is driven by advances in recombinant DNA technology, protein engineering and bioinformatics, all of which are critical in the discovery, tailoring and optimization of enzymes for industrial processes. In this article we review these key technological innovations, as well as highlight the strategic application of these tools in the development of biocatalysts in the production of advanced pharmaceutical intermediates.