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Multifunctional gadolinium oxide nanoparticles: towards image-guided therapy

Stephane Roux, Anne Charlotte Faure, Celine Mandon, Sandrine Dufort, Charlotte Riviere, Jean-Luc Bridot, Brice Mutelet, Christophe A Marquette, Veronique Josserand, Geraldine Le Duc, Alain, Le Pape, Claire Billotey, Marc Janier, Jean-Luc Coll, Pascal Perriat and Olivier Tillement

Owing to their multifunctional character, nanoparticles appear well suited for combining sensing, imaging and therapy. Nanoparticles composed of a gadolinium oxide core and a polysiloxane shell were designed for the detection of biomolecules, fluorescence and MRI, and for cancer therapy. Each component (gadolinium oxide core and polysiloxane shell) of these nanoparticles plays a crucial role and enables the resulting nanoparticles to emit intense but transient light and/or long-lived and highly photostable light, to enhance the contrast of magnetic resonance images, to improve the colloidal stability, to specifically interact with biomolecules, to absorb x‑ray photons and to capture thermal neutrons. The hybrid gadolinium oxide nanoparticles exhibit a great potential for sensing applications and for image-guided therapy.