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Inflammation in atherosclerosis: Role in pathogenesis and promising therapeutic strategies

Alexander V. Blagov, Nikolay K. Sadukhov, Ilya I. Eremin, Vasily N. Sukhorukov, Irina I. Nadelyaeva, Mikhail A. Popov, Alexander N. Orekhov

Studying the factors influencing the development of inflammation in atherosclerosis is an important step to better understand the pathogenesis of this disease. In this review, we consider the process of development of inflammation in atherosclerosis, the influence of various cell types on the development of inflammation in atherosclerosis, and the relationship between the inflammatory response and the progression of the disease. In addition, several strategies for anti-inflammatory therapy of atherosclerosis have been proposed, which may find their practical application in the near future.