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Infection - An Amendment to the Stroke Model Guidelines

Odilo Engel, Ulrich Dirnagl and Andreas Meisel

Many publications show that infections have a tremendous impact on both general medical and neurological outcome. Summarizing the findings from several experimental studies we conclude that controlling infections in animal models of stroke is indispensable similar to checking body temperature in order to avoid misinterpretations of study results. In our manuscript we followed the structure used in the original article to provide a consistent outline. In brief, we reviewed the necessity of monitoring post-stroke infections, followed by a section on how to exclude the impact of infections in stroke models.