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High-dose methotrexate complicated by acute tubular necrosis: a case report

Myke R Green, Sajeel A Chowdhary, Lisa M Chalmers, Kris M Lombardi and Marc C Chamberlain

High-dose methotrexate (HDMTX) forms the basis for the majority of chemotherapy regimens for primary CNS lymphoma. Several toxicities are encountered with HDMTX, of most concern is acute nephrotoxicity. This case report illustrates several aspects of HDMTX-related renal injury.