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Effects of compound glycyrrhizin on serum IFN-γ, IL-10 and immunological index in patients with alopecia areata

Xinguo Xue

Aims: To investigate the effect of compound glycyrrhizin in the treatment of alopecia areata and its effect on serum Interferon-γ (IFN-γ), Interleukin-10 (IL-10) and other immunological indexes.

Methods: 150 patients with alopecia areata were randomly divided into study group and control group, 75 cases in each group. The cases in the control group were treated with LingDan tablets. The cases in the study group were treated with the compound glycyrrhizin tablets based on control group’s treatment. The two groups were treated for 3 months. The severity of alopecia tool (SALT) score, IFN-γ and IL-10 levels, immunological indicators were recorded before and after treatment.

Results: The total effective rate of the study group and the control group were 93.3%, 77.3% after the treatment (P<0.05). The SALT scores were decreased in both groups, and the SALT scores of the study group was lower than that of the control group (P<0.05). Compared with the control group, the levels of IFN-γ were decreased and IL-10 were higher in the study group. The levels of CD3+, CD4+, CD4+/CD8+, IgA, IgG and IgM were both increased, which was significantly higher than those in the control group (P<0.05), indicating that the improvement of the study group was significantly better than that of the control group. The incidence of adverse reactions in the study group and the control group was 2.7%, 4%, respectively. (P>0.05)

Conclusion: On the basis of LingDan tablets and minoxidil tincture at the skin, adding compound glycyrrhizin tablets in the treatment of alopecia areata has a high clinical total effective rate, which can improve the condition and immunization of alopecia areata and regulate the level of Th1/Th2 cytokines. Our study provides a new sight of compound glycyrrhizin in the clinical treatment of alopecia areata and deserves further clinical application.