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Diabetic ketoacidosis in children and youth

Denis Daneman & Meranda Nakhla

Diabetic ketoacidosis (DKA) remains a common complication of Type 1 diabetes, both at the time of diagnosis of the disorder and in those with established diabetes. DKA results from profound insulin deficiency producing hyperglycemia, osmotic diuresis and ketogenesis, eventually leading to dehydration and metabolic acidosis. Provided here is a review of the approach to treatment and prevention of DKA and its complications.