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Bisphosphonates in pediatric rheumatology: A review

Anita Dhanrajani & Raju P. Khubchandani

Bisphosphonates are osteoclast inhibiting agents that have been used in adult osteoporosis for the last three decades. Success with their earliest reported indication in children for osteogenesis imperfecta has lead to their use for secondary osteoporosis in rheumatological disorders and inflammatory bone diseases in this age group besides some other indications. This review aims to discuss the current usage of these molecules in pediatric rheumatological diseases, the mechanism of action and evidence base for these, adverse effects, monitoring, and controversies surrounding their use.